For the Holidays, Hong Kong Decks Its Skyscrapers in Lights

HONG KONG — For the past few weeks, Santa Claus, looking cheerful and surrounded by twinkling stars and ornaments, has been dancing on the sides of skyscrapers.

The images, rendered in tens of thousands of lights across Hong Kong, are varied: in one part of town, Santa is riding a dolphin; not far away, giant beribboned parcels decorate the exterior of another building, blinking gently many floors above ground.

Chinese culture adores lights, and the Hong Kong skyline has some of the biggest, brashest and most colorful in the world, year-round. Shop fronts, signposts, entire buildings are lit up — some with undulating and flickering effects — as the sun sets each evening, enveloping the entire city in an orange glow.

But this time of year, the spectacle ratchets up several notches. Out come vast, multicolored, complex designs that span many floors and make the Rockefeller Center in New York and Oxford Street in London pale by comparison. Frolicking reindeer, bobble-hatted snowmen, enormous Christmas trees adorn dozens of buildings, sometimes to startling effect.

The man behind many of these images is Terence Wong, who trained as an electrician and once did stage lighting work for theaters. Thirty years ago, Mr. Wong was asked by a Hong Kong property developer to add a bit of seasonal pizazz to a new complex of office buildings in Tsim Sha Tui East, an area that was then off the beaten track. He has not looked back.

“It is my passion,” Mr. Wong, 54, said in an interview in his office, which is filled with files and lighting accessories. “I never want to stop.”

The first job involved simple stars suspended from the tops of buildings. Over the years, Mr. Wong has made the displays ever more complex, as he and his workers have learned how to affix strings of light bulbs to the glass facades of buildings using window-cleaning platforms.

The displays, Mr. Wong said, typically cost anywhere between 20,000 and 100,000 Hong Kong dollars, or about $2,600 to $13,000, depending on the size and intricacy of the image. But for many building owners, sprucing up exteriors is as much a part of the holiday season as tree lights are for operators of shopping centers or private citizens in Western cultures.

Downturns in the economy, Mr. Wong said, do not prompt building owners to hold back on this expenditure. When an epidemic of severe acute respiratory syndrome, or SARS, hit Hong Kong in 2003, causing tourism to evaporate and the economy to buckle, building owners actually spent more on the displays, Mr. Wong said.

Likewise, spending this year has not changed, even though the Hong Kong economy, hit by the global downturn and slower growth in China, is expected to have grown just 1.2 percent in 2012. That is down from 4.9 percent last year and 6.8 percent the year before that. The displays are typical of the resilience in consumer spending in Hong Kong, where unemployment remains low — 3.4 percent, according to the latest government figures.

Light displays are deeply ingrained in Chinese folk culture. Lanterns have been objects of artistic expression and status symbols for centuries, as have the elaborate fireworks displays that feature in major celebrations to this day. In the same vein, prominent buildings are brightly lit all over China at night, often changing colors every few seconds, while light shows are a popular form of public entertainment.

In Hong Kong, various factors have given the phenomenon an extra intensity. Unlike cities on the Chinese mainland, Hong Kong has sizable Christian and Western communities, so Christmas and Jan. 1 join the Lunar New Year as important festivals.

Then there is the sheer commercialism of Hong Kong, which derives a large part of its wealth from millions of Chinese tourists. “For every mainland Chinese who visits Singapore or New York today, there are 20 or more who go to Hong Kong,” Donna Kwok, an economist at HSBC, said in a research report this month. By 2015, these visitors are expected to spend 55 billion dollars, equivalent to one-third of Hong Kong’s gross domestic product, she added.

Attractions like the city’s nightly light-and-laser show, which involves more than 40 buildings and is organized by the Hong Kong tourism board, are an important draw, and visitors flock in their thousands to see it each evening.

The holiday bonanza of decorative lights on buildings lasts about three months. Once Christmas and the Western calendar New Year are over, the displays are changed to focus on the Lunar New Year celebrations, which mark the high point of the Chinese calendar and fall in January or February. “Merry X-mas” wishes are replaced with Chinese characters wishing good luck and wealth for the coming year. Santa Clauses morph into Chinese money gods. Symbols of fortune and happiness replace stars and snowflakes.

Mr. Wong’s illuminations started going up in late November and will stay up until a week or two after the start of the Year of the Snake, on Feb. 10.

Mr. Wong, however, stays busy year-round, looking after the manufacture of the strings of light bulbs and other equipment he needs and preparing the designs for the next season. He never recycles old images, he said, but designs three new proposals for each decoration job that Shun Sze Lighting, the company he founded in 1976, bids for.

Given that Shun Sze does about two dozen buildings per year, that is a lot of drawings — but Mr. Wong does not seem to mind.

“Every day, I think about Christmas — all year,” he beamed. “Santa Claus is coming — every day!”

Joanne Lam contributed reporting.

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Well: With Help Here and There, Preserving Independence in Old Age

My 92-year-old aunt, who is cognitively impaired and requires a walker or wheelchair to get around, still lives in her own apartment, where round-the-clock home health aides help her get to and from the bathroom, bathe, dress and undress, and go outside each day for some fresh air. The aides shop, prepare and serve meals, do light housekeeping and make sure she takes her medications on time.

But last month, my aunt’s long-term care insurance ran out, and her meager savings will soon do the same. Then what?

Her daughters, both of whom work to support their families, cannot afford the $150 a day for 24-hour care by a certified home health aide, and my aunt has nothing to sell that could bring in the needed cash. Nor does she yet qualify for Medicaid or have a terminal illness that would justify hospice care, which would be covered by Medicare.

Complicating matters, her daughters long ago promised that they would not put her in a nursing home.

Such dilemmas are increasingly common as people live longer. The number of Americans 65 and older is expected to double to 80 million in the next three decades. People 85 and older are the fastest-growing age group; by 2020, there will be 6.6 million people in that age bracket, when rates of debilitating ailments soar.

Most Americans over 65 will eventually need help with the so-called tasks of daily living — eating, dressing, bathing, shopping and the like. But with family members spread all over the map or unable to be full-time caregivers for other reasons, the need for new and better options will only increase.

When asked, 80 to 90 percent of older people say they want to remain in their own homes as long as possible. Yet remaining in one’s home indefinitely is not always the best choice, even if it is financially feasible. As life draws near a close, many older adults need more care than can be provided safely at home. Simply finding reputable home health aides can be a nightmare, and family members often are forced to fill gaps in even the best caregiving plans.

The challenge is all the more difficult when no one has thought through the options before a serious illness or injury makes it impossible for elders to return home without full-time help.

Many elders living independently need outside help long before they require round-the-clock care. A range of assistance and housing alternatives has rapidly sprung up to meet this demand. Many focus on improving accessibility in the home and access to neighborhood conveniences.

An older person living in the suburbs who can no longer drive may become isolated, lonely and at risk of malnutrition if there is no person or community service to shop for her and take her places. Even stairs are a major obstacle.

Elinor Ginzler, director of the Cahnmann Center for Supportive Services at the Jewish Council for the Aging in Rockville, Md., writes that “the ability to age in place is greatly determined by the physical design and accessibility of a home, as well as community features like the availability of nearby services and amenities, affordable housing and transportation options.”

Organizations like Staying in Place, a nonprofit group of volunteers, helps people age 50 and older in Woodstock, N.Y., and surrounding communities “maintain active, independent, fulfilling lives in their own homes.” For $125 a year (plus $50 for each additional household member over 50), the organization assists with paperwork and technology; free or low-cost transportation; referrals to discounted service workers; information about, and transport to, local classes and cultural and social activities; and recommendations for home health care agencies and personnel.

Other services that are free or low-cost include Meals on Wheels; friendly visiting; shopping services accessed by phone or computer; activities at senior centers; and adult day care centers.

There are also more costly commercial organizations like Home Instead Senior Care, an international network of more than 900 independently owned franchises that provide in-home nonmedical care for elders and support for their caregivers.

The organization sponsored a yearlong online study of 1,631 caregivers, 697 of whom were assisted by paid in-home nonmedical care. The study found that people receiving the additional paid care required 25 percent fewer doctor visits and were more likely to participate in adult day care.

Sadly, many aides are seriously underpaid. Home Instead, for instance, has lobbied to keep home health care aides exempt from minimum wage standards.

Henry Cisneros, former secretary of the United States Department of Housing and Urban Development and editor of the book “Independent for Life: Homes and Neighborhoods for an Aging America,” points out that “Americans are aging in traditional homes, neighborhoods and communities that were designed for yesterday’s demographic realities, not those of today or the future.”

Mr. Cisneros advocates changing our communities so that the elderly can remain in them. “Homes can be retrofitted, new age-appropriate homes built, existing neighborhoods reconnected, and new communities planned,” he wrote. For example, to accommodate declining eyesight, homes can be fitted with brighter bulbs, better lighting locations, easily accessed controls and nighttime guide lights.

Mr. Cisneros sees a pressing need for affordable packages of home modifications and maintenance to make residences more suitable for older people.

“A certified renovation package for aging in place could include roll-under kitchen and bathroom sinks, grab bars, curbless showers, lever faucets and door handles, a zero-step entrance, and wider doors and hallways,” he wrote.

While such changes have a price tag, they may cost a lot less than current care alternatives for the elderly.

Needed changes at the community level include affordable small-scale housing and cluster housing situated in walkable communities with nearby amenities, businesses, health facilities and public transportation.

Borrowing from the design of assisted living facilities, individual dwelling units might be located around a common space that includes dining areas and social rooms.

For elders who want to be near family members yet maintain their independence, so-called accessory dwelling units with their own kitchens and bathrooms are being built near or attached to family homes.

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How to Know When Home Alone Is No Longer a Good Idea

Paula Spencer Scott, senior editor at Caring.com, recently compiled a guide to help families determine when the time has come to move older relatives from their homes and into a more supportive environment or, alternatively, to bring in a home health aide who can provide assistance. These signs to look for and questions to ask are adapted from Ms. Scott’s recommendations.

¶ Recent accidents or close calls, like a fall, medical scare or minor car accident.

¶ A slow recovery. How well was a recent illness weathered? Did it develop into something serious? Was medical help sought when needed?

¶ Worsening of a chronic health condition. As problems like chronic obstructive pulmonary disease, dementia or congestive heart failure progress, more help will be needed.

¶ Greater difficulty managing the so-called activities of daily living, like dressing, bathing and cooking.

¶ Bodily changes, like obvious weight loss or gain, increased frailty or unpleasant body odor.

¶ A loss of active friendships, including outings with friends, visits with neighbors or participation in religious or other group activities.

¶ Days spent without leaving the house, perhaps because of difficulty driving or a fear of using public transportation.

¶ Is someone checking in regularly? If not, is there a home-safety alarm system, a personal alarm system or a daily calling service in place?

¶ Is someone nearby to assist if there’s a fire, earthquake, flood or other disaster, and does the older resident understand plans for a catastrophe?

¶ Mail in a chaotic state, scattered about and unopened. Are there unpaid overdue bills, surprising thank-you notes from charities, piles of unread magazines?

¶ If an older relative is still driving, go along for a ride and look for failure to fasten the seat belt or heed dashboard warning lights; signs of tension, preoccupation or distraction while driving; damage to the vehicle that may indicate carelessness.

¶ In the kitchen, signs of excess or forgetfulness, like perishables well past their expiration dates.

¶ Favorite appliances are broken but not scheduled for repair.

¶ Signs of fires. Look for charred stove knobs or pot bottoms, potholders with burned edges, a discharged fire extinguisher. Do smoke and carbon monoxide detectors have live batteries?

¶ A once-neat home now cluttered, spills that were not cleaned up, grime coating bathroom and kitchen appliances or an overflowing laundry basket.

¶ Neglected plants or pets.

¶ Signs of neglect outside the home, like broken windows, debris-filled gutters and drains, uncollected rubbish and an overstuffed mailbox.

¶ Ask friends and neighbors whether your family member’s behavior has changed lately.

¶ Ask the person’s doctor whether you should be concerned about the person’s health or safety and whether a home assessment by a social worker or geriatric care manager may be advisable. If you expect resistance from the person, ask the doctor to “prescribe” a professional evaluation.

¶ If you are the primary caregiver, how are you doing? Are you increasingly exhausted, depressed or becoming resentful of the sacrifices you have to make to care for the person?

¶ Consider your older relative’s emotional state. If she is riddled with anxieties or increasingly lonely, then it may be time to make a move for reasons other than health and safety.

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India Ink: Protests Over Rape Turn Violent in India

NEW DELHI— Protests over a recent gang rape quickly gained force over the weekend, tapping into longstanding fury against entrenched corruption and lopsided justice, and leading to clashes with the police.

Seven days of demonstrations peaked Sunday, as thousands of people joined women’s and students’ groups despite a hastily enacted ban on protesting in New Delhi. The crowds taunted the police and attacked the car of a member of Parliament. The police, in turn, fired tear gas and water cannons, beat protesters with bamboo sticks and arrested dozens.

“Many students who were protesting peacefully were attacked,” said Jayati Ghosh, a professor of economics at Jawaharlal Nehru University, who had joined the protest with her daughter. “These are patriotic and respectable citizens. You cannot respond to them in this ham-handed manner.”

Kulsoom Rashid, 27, rubbed her eyes and said she had been tear-gassed. “This is how they are responding,” she said, seething. “Hundreds of rapists are running scot-free, and the entire Delhi police is standing here to stop people like me?”

By late afternoon Sunday, political parties had joined the crowd, increasing the number of confrontations with the authorities. Protesters overturned a car, and clashes became fierce.

After several recent, highly publicized rape cases, India has been struggling to come to grips with the scale of the vastly underreported problem. Even when rapes are reported, suspects are rarely found and arrested.

In the most recent case, a 23-year-old medical student who boarded what she thought was a public bus on Dec. 16 was brutally raped and beaten nearly to death by a group of men. Six suspects are in jail.

The rapid reaction has done little to stem public anger. On Sunday, protesters jostled with the police, calling them “cowardly,” “corrupt” and “inept,” as they tried to push through the cordon.

“Why don’t you come and join us?” one agitated protester asked a senior police officer. “Aren’t you angry at what happened?”

The crowd swarmed over the India Gate monument in the city center and were prevented from marching on the Rashtrapati Bhavan, or presidential palace, only by the intervention of hundreds of police officers, many of them from the country’s elite Rapid Action Force.

“These people have lost patience with a government that has no sense of justice, no sense of accountability and is totally corrupt at the top,” said Prem Shankar Jha, a former editor of the Hindustan Times.

Corruption has become a dominant political theme in India in the past several years, starting with the Anna Hazare movement of 2011 and continuing this year with the creation of a political party by one of Mr. Hazare’s former disciples, Arvind Kejriwal.

The protests on Sunday recalled demonstrations in 2011, with the focus shifted from government corruption to the difference in security between the elite and the rest of India.

“These people see that the cops are only protecting the ministers and the top bureaucrats, while the average person on the street, she feels very vulnerable,” said Paranjoy Guha Thakurta, a political analyst and commentator.

Some experts say that the gap is undermining claims of legitimacy by the authorities.

“The consistent thing we have been seeing for the last couple of years is that people have come to believe that the state has become an instrument largely for the benefit and protection of a few — and mostly politicians,” said Pratap Bhanu Mehta, president of the Center for Policy Research in New Delhi. “That momentum is producing an open contempt of the state.”

Just to reach the protest sites, the crowds defied multiple government efforts to keep them away. Officials had shut down many central subway stations, curtailed bus service, diverted traffic and even invoked a law making it illegal for more than a few people to gather. Dozens who had camped overnight at protests sites were arrested and dragged away. Top government officials pleaded on national TV Saturday night for people to stay away.

The protest organizers demanded that the courts speed the progress of about 100,000 rape cases; that the police to pledge to register rape complaints promptly; that Parliament hold a special session to strengthen laws on rape, sexual harassment and child abuse; and that the Delhi police commissioner be fired for his handling of the protests.

The demands offer a hint of the deep distrust with which most Indians regard the police.

“If there is one state institution that people fear and distrust the most, it’s the police,” Mr. Mehta said. “A lot of people, particularly women, find police more fearsome than the guys out there on the street.”

There are more than 80,000 human rights complaints filed in India against police officers every year, according to Mr. Jha, the former Hindustan Times editor. That represents a small fraction of the actual number of crimes committed by officers, he said, most of which are sexual assaults against women.

Niharika Mandhana and Sruthi Gottipati contributed reporting.

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Seahawks roll past 49ers in noisy Seattle 42-13

SEATTLE (AP) — Fueled by its deafening home crowd, the Seattle Seahawks locked up their spot in the postseason Sunday night.

They also reinforced the notion no one in the NFC wants to see them when the playoffs begin, even if they are a wild card.

Russell Wilson threw a career high four touchdown passes to move into second place for most TD passes by a rookie. Marshawn Lynch scored two first-quarter TDs, and the Seahawks blew out the San Francisco 49ers 42-13.

Richard Sherman returned a blocked field goal 90 yards for another touchdown as the Seahawks (10-5) jumped to a 21-0 lead. That only added to an already hyped crowd on a typically cold and rainy December night, with noise echoing off the walls and overhanging roof of CenturyLink Field that might have been heard all the way across Puget Sound.

No one cared about the cold rain. Not with the performance they were seeing on the field. And not with a ticket to the postseason guaranteed thanks to Seattle's first 10-win season since 2007.

Most likely Seattle will be the No. 5 seed in the NFC. There remains a slight chance of winning the NFC West if the Seahawks beat St. Louis in the season finale and Arizona can upset the 49ers in San Francisco.

The Seahawks, 7-0 at home, delayed San Francisco (10-4-1) from celebrating a division title on Seattle's turf. They turned Jim Harbaugh's 49th birthday into a miserable, wet evening.

Whether home or road, the Seahawks are a scary postseason opponent with the way they are playing.

Seattle was the first team since 1950 to score at least 50 points in consecutive weeks thanks to its 58-0 win over Arizona and 50-17 victory against Buffalo. It seemed inconceivable the scoring binge could continue against San Francisco, the best scoring defense in the NFL.

But it did.

Seattle has outscored its last three opponents 150-30.

The 42 points were the most allowed since Harbaugh took over the 49ers, and the most San Francisco yielded since 45 to Atlanta in 2009. It was the perfect way for Pete Carroll to snap a three-game losing streak against his rival.

Lynch finished with 111 yards on 26 carries, his third straight game against the 49ers topping 100 yards. Wilson wasn't asked to do much — other than throw touchdown passes.

He hit Lynch on a 9-yard TD in the first quarter, Anthony McCoy for a 6-yarder late in the first half, and Doug Baldwin on 4 and 6 yard TDs in the second half.

Wilson now has 25 TD passes, one behind Peyton Manning's NFL rookie record of 26. He finished 15 of 21 for 171 yards. His only incompletion in the first half was a deflected pass that Patrick Willis intercepted.

Wilson led Seattle on scoring drives of 9, 12, 13 and 15 plays. He was never threatened by Aldon Smith, who remained stuck on 19 1-2 sacks for the season thanks to the play of Seattle left tackle Russell Okung.

The Seahawks were 11 of 13 on third-down conversions. And Wilson was the clear winner in the matchup of young quarterbacks.

San Francisco's Colin Kaepernick had already proven himself capable of winning on the road with victories in New Orleans and last week in New England. But Seattle is a different beast, widely regarded by players as the loudest venue in the NFL. His inexperience playing in such an environment showed. He was flustered and disorganized at the line of scrimmage, letting the noise from Seattle's fans affect him.

Kaepernick's forgettable night was capped when Sherman stepped in front of his pass for Randy Moss at the back of the end zone on the first play of the fourth quarter for his seventh interception of the season.

Kaepernick was 19 of 36 for 244 yards with an 18-yard TD pass to Delanie Walker with 1:40 left. Frank Gore had just 28 yards on six carries after rushing for a season-high 131 when the teams met in Week 7.

San Francisco played without defensive tackle Justin Smith due to an elbow injury that ended a streak of 185 straight starts. The 49ers lost tight end Vernon Davis in the first quarter with a concussion suffered when he was knocked off his feet on a huge hit along the sideline from Seattle safety Kam Chancellor that looked legal but drew a penalty for hitting a defenseless receiver.

The injuries kept coming when starting cornerback Tarell Brown was on the ground clutching his right knee early in the second quarter and had to be helped off the field. Brown returned in the second half.

And wide receiver Mario Manningham went down with a left leg injury early in the third quarter when he was tackled low by Leroy Hill and fumbled.

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Online: http://pro32.ap.org/poll and http://twitter.com/AP_NFL

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Gun Makers Based in Connecticut Form a Potent Lobby

Gun owners packed a hearing room in the Connecticut capital, vowing to oppose a bill that would require new markers on guns so that they are easier to trace.

One after another, they testified that the technology, called microstamping, was flawed and would increase the cost of guns.

But the witness who commanded the most attention in Hartford that day in 2009 was a representative of one of Connecticut’s major employers: the Colt Manufacturing Company, the gun maker.

The Colt executive, Carlton S. Chen, said the company would seriously consider leaving the state if the bill became law. “You would think that the Connecticut government would be in support of our industry,” Mr. Chen said.

Soon, Connecticut lawmakers shelved the bill; they have declined to take it up since. Now, in the aftermath of the school massacre in Newtown, the lawmakers are formulating new gun-control measures, saying the state must serve as a national model.

But the failed effort to enact the microstamping measure shows how difficult the climate has been for gun control in state capitals. The firearm companies have played an important role in defeating these measures by repeatedly warning that they will close factories and move jobs if new state regulations are approved.

The companies have issued such threats in several states, especially in the Northeast, where gun control is more popular. But their views have particular resonance in Connecticut, a cradle of the American gun industry.

Like manufacturing in Connecticut over all, the state’s gun industry is not as robust as it once was. Still, Connecticut remains the seventh-largest producer of firearms in the country, according to federal data.

Colt, based in Connecticut since the 1800s, employs roughly 900 people in the state. Two other major gun companies, Sturm, Ruger & Company and Mossberg & Sons, are also based in the state. In all, the industry employs about 2,000 people in Connecticut, company officials said.

Gun-control advocates have long viewed Hartford, the capital, as hospitable terrain, because Connecticut is a relatively liberal state and already has more gun restrictions than most. Democrats control both houses of the legislature.

Yet lawmakers in Hartford did more than shelve the microstamping bill in 2009. They also declined to push a bill last year that would have banned high-capacity ammunition magazines — the very accessory used by Adam Lanza to kill 26 people, including 20 children, at Sandy Hook Elementary School in Newtown.

In several states, the gun companies have enlisted unions that represent gun workers, mindful that Democratic lawmakers who might otherwise back gun control also have close ties to labor.

In Connecticut, the United Automobile Workers, which represents Colt workers, has testified against restrictions. The union’s arguments were bolstered last year when Marlin Firearms, a leading manufacturer of rifles, closed a factory in Connecticut that employed more than 200 people. Marlin cited economic pressures, not gun regulation, for the decision, but representatives of the gun industry have said the combination of the two factors could spur others to move.

State law significantly restricts the ability of corporations to make political donations in Connecticut. Employees of Connecticut gun companies have contributed several thousand dollars in total in recent years to state candidates, mostly Republicans, according to an analysis of state records.

Financially, the gun companies and their employees in Connecticut have exerted influence by donating to national groups, especially the National Rifle Association, which have in turn helped Connecticut gun rights groups, according to interviews and financial records.

But it appears that in Hartford, the companies are relying largely on economic arguments.

Their strategy has been led by the industry’s trade group, the National Shooting Sports Foundation, which happens to have its national headquarters in Newtown, a few miles from the site of the shootings.

When Connecticut lawmakers held a hearing in 2011 on the measure to ban high-capacity ammunition magazines, the director of government regulations for the foundation, Jake McGuigan, opened his testimony with some statistics.

Mr. McGuigan told lawmakers that the state’s gun companies contributed $1.3 billion to the Connecticut economy, through their own operations and those of their suppliers.

“Each year, they get courted by other firearm-friendly states, like Idaho, Virginia, North Carolina,” Mr. McGuigan said. He later added, “It’s not an idle threat.”

The federation and Colt have declined to comment on gun-control legislation since the school killings.

“Our hearts go out to our fellow Connecticut residents who have suffered such unimaginable loss,” Colt said in a statement. “We do not believe it is appropriate to make further public statements at this very emotional time.”

Gun-control advocates in Hartford said the gun companies’ strategy was shrewd because it allowed Democratic lawmakers to oppose new regulations while proclaiming that they had not bowed to the National Rifle Association.

Michael Moss and Griff Palmer contributed reporting.

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Genetic Gamble : Drugs Aim to Make Several Types of Cancer Self-Destruct

C.J. Gunther for The New York Times

Dr. Donald Bergstrom is a cancer specialist at Sanofi, one of three companies working on a drug to restore a tendency of damaged cells to self-destruct.

For the first time ever, three pharmaceutical companies are poised to test whether new drugs can work against a wide range of cancers independently of where they originated — breast, prostate, liver, lung. The drugs go after an aberration involving a cancer gene fundamental to tumor growth. Many scientists see this as the beginning of a new genetic age in cancer research.

Great uncertainties remain, but such drugs could mean new treatments for rare, neglected cancers, as well as common ones. Merck, Roche and Sanofi are racing to develop their own versions of a drug they hope will restore a mechanism that normally makes badly damaged cells self-destruct and could potentially be used against half of all cancers.

No pharmaceutical company has ever conducted a major clinical trial of a drug in patients who have many different kinds of cancer, researchers and federal regulators say. “This is a taste of the future in cancer drug development,” said Dr. Otis Webb Brawley, the chief medical and scientific officer of the American Cancer Society. “I expect the organ from which the cancer came from will be less important in the future and the molecular target more important,” he added.

And this has major implications for cancer philanthropy, experts say. Advocacy groups should shift from fund-raising for particular cancers to pushing for research aimed at many kinds of cancer at once, Dr. Brawley said. John Walter, the chief executive officer of the Leukemia and Lymphoma Society, concurred, saying that by pooling forces “our strength can be leveraged.”

At the heart of this search for new cancer drugs are patients like Joe Bellino, who was a post office clerk until his cancer made him too sick to work. Seven years ago, he went into the hospital for hernia surgery, only to learn he had liposarcoma, a rare cancer of fat cells. A large tumor was wrapped around a cord that connects the testicle to the abdomen. “I was shocked,” he said in an interview this summer.

Companies have long ignored liposarcoma, seeing no market for drugs to treat a cancer that strikes so few. But it is ideal for testing Sanofi’s drug because the tumors nearly always have the exact genetic problem the drug was meant to attack — a fusion of two large proteins. If the drug works, it should bring these raging cancers to a halt. Then Sanofi would test the drug on a broad range of cancers with a similar genetic alteration. But if the drug fails against liposarcoma, Sanofi will reluctantly admit defeat.

“For us, this is a go/no-go situation,” said Laurent Debussche, a Sanofi scientist who leads the company’s research on the drug.

The genetic alteration the drug targets has tantalized researchers for decades. Normal healthy cells have a mechanism that tells them to die if their DNA is too badly damaged to repair. Cancer cells have grotesquely damaged DNA, so ordinarily they would self-destruct. A protein known as p53 that Dr. Gary Gilliland of Merck calls the cell’s angel of death normally sets things in motion. But cancer cells disable p53, either directly, with a mutation, or indirectly, by attaching the p53 protein to another cellular protein that blocks it. The dream of cancer researchers has long been to reanimate p53 in cancer cells so they will die on their own.

The p53 story began in earnest about 20 years ago. Excitement ran so high that, in 1993, Science magazine anointed it Molecule of the Year and put it on the cover. An editorial held out the possibility of “a cure of a terrible killer in the not too distant future.”

Companies began chasing a drug to restore p53 in cells where it was disabled by mutations. But while scientists know how to block genes, they have not figured out how to add or restore them. Researchers tried gene therapy, adding good copies of the p53 gene to cancer cells. That did not work.

Then, instead of going after mutated p53 genes, they went after half of cancers that used the alternative route to disable p53, blocking it by attaching it to a protein known as MDM2. When the two proteins stick together, the p53 protein no longer functions. Maybe, researchers thought, they could find a molecule to wedge itself between the two proteins and pry them apart.

The problem was that both proteins are huge and cling tightly to each other. Drug molecules are typically tiny. How could they find one that could separate these two bruisers, like a referee at a boxing match?

In 1996, researchers at Roche noticed a small pocket between the behemoths where a tiny molecule might slip in and pry them apart. It took six years, but Roche found such a molecule and named it Nutlin because the lab was in Nutley, N.J.

But Nutlins did not work as drugs because they were not absorbed into the body.

Roche, Merck and Sanofi persevered, testing thousands of molecules.

At Sanofi, the stubborn scientist leading the way, Dr. Debussche, maintained an obsession with p53 for two decades. Finally, in 2009, his team, together with Shaomeng Wang at the University of Michigan and a biotech company, Ascenta Therapeutics, found a promising compound.

The company tested the drug by pumping it each day into the stomachs of mice with sarcoma.

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At Western Wall, a Divide Over Prayer Deepens

Rina Castelnuovo for The New York Times

Members of Women of the Wall prayed this month while wearing tallits, fringed prayer shawls, and tefillin, leather prayer boxes, both of which Jewish men are told to wear.

JERUSALEM — The face-off at the security gate outside the Western Wall one Friday this month was familiar: for more than two decades, women have been making a monthly pilgrimage to pray at one of Judaism’s holiest sites in a manner traditionally preserved for men, and the police have stopped them in the name of maintaining public order.

Rina Castelnuovo for The New York Times

Bonna Devora Haberman, 52, of Women of the Wall, was confronted by the police this month after trying to bring in her prayer shawl.

But after a flurry of arrests this fall that set off an international outcry, the women arrived for December’s service to find a new protocol ordered by the ultra-Orthodox rabbi who controls the site. To prevent the women from defying a Supreme Court ruling that bars them from wearing ritual garments at the wall, they were blocked by police officers from bringing them in.

“How can you say this to me?” demanded a tearful Bonna Devora Haberman, 52, a Canadian immigrant who helped found the group Women of the Wall in 1988. “I’m a Jew. This is my state.”

The officer was unmoved. “At the Western Wall, you can’t pray with a tallit,” he said, referring to the fringed prayer shawl in Ms. Haberman’s backpack. “You can’t go in with it.”

After years of legislative and legal fights, the movement for equal access for people to pray as they wish at the site has become a rallying cause for liberal Jews in the United States and around the world, though it has long struggled to gain traction here in Israel, where the ultra-Orthodox retain great sway over public life.

This has deepened a divide between the Jewish state and the Jewish diaspora, in which some leaders have become increasingly vocal in criticizing Israel’s policies on settlements in the Palestinian territories; laws and proposals that are seen as antidemocratic or discriminatory against Arab citizens; the treatment of women; and the ultra-Orthodox control over conversion and marriage.

“When my kids start expressing frustration with Israel as a society because what they hear and see from a distance is not welcoming to them in their religious practice — that’s not good for the Jewish people, let alone for the state of Israel,” said Rabbi Steven C. Wernick, the director of the United Synagogue of Conservative Judaism.

Rabbi Levi Weiman-Kelman, an American immigrant who runs Kol Haneshama, a leading Reform synagogue here, said Women of the Wall “is an issue that really brings out the gap between Israeli Jews and American Jews.”

While more than 60 percent of Jews in the United States identify with the Reform or Conservative movements, where women and men have equal standing in prayer and many feminists have adopted ritual garments, in Israel it is one in 10. Instead, about half call themselves secular, and experts say that most of those consider Orthodoxy as the true Judaism, feel alienated from holy sites like the Western Wall, and view a woman in a prayer shawl as an alien import from abroad.

(Jewish law requires only men to pray daily, though many women have taken on the obligation voluntarily. It also says women should not dress like men.)

“Secular Israelis do not see this as their problem; to them it’s a bunch of crazy American ladies,” said Shari Eshet, who represents the New York-based National Council of Jewish Women here. “It’s embarrassing for Israel, it’s embarrassing for Jews, and the American Jewish community is beginning to understand that it’s a slippery slope here.”

The increased agitation around the wall is part of a broader clash over Judaism and gender that has roiled Israel in recent months. Women have won lawsuits against segregation on buses and sidewalks imposed in religious neighborhoods. But a bus line recently stopped accepting advertisements with images of people after religious vandals routinely blacked out women’s faces in the name of modesty.

In January, speakers at a conference on health and Jewish law canceled their appearances because women were barred from the podium — a demand of the most Orthodox — while the chief rabbi of the air force quit after religious soldiers were not excused from events where women sang.

These controversies concern the imposition of Orthodox doctrine in secular spheres. More complicated are questions of how Judaism itself should be practiced. This spring, the Supreme Court ruled that the government must pay the salary of a Reform rabbi along with hundreds of Orthodox ones. A small group of Jerusalem restaurants has been seeking an alternative kosher certification system to the one run by the government’s rabbinical council.

“The next chapter of what it means to be a Jewish state is being defined right now,” said Elana Sztokman, the director of the Jewish Orthodox Feminist Alliance, who is writing a book that includes a chapter about Women of the Wall. “We have to figure out what does Israel want, what role do we really want religion to have in this state? And it’s happening on the backs of women.”

Irit Pazner Garshowitz and Myra Noveck contributed reporting.

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2 bombers target mobile phone firms in Nigeria

KANO, Nigeria (AP) — Authorities blame a radical Islamist sect for twin suicide car bombings targeting two major mobile phone companies, an official said Saturday, blacking out a top operator’s network in most of Nigeria‘s northern commercial hub.

A suicide bomber drove an explosive-laden car into the facilities of the Nigerian subsidiary of Bharti Airtel Ltd. of India at about 8 a.m. in the city of Kano, said Capt. Iweha Ikedichi, who speaks for a special taskforce deployed in Kano to reduce the threat of the Islamic rebels known as Boko Haram. The attack left an Airtel worker injured, authorities said. It also damaged a switch station, said James Eze, an Airtel spokesman. He said the company was still assessing how bad the damage was, but declined to comment further.

Switch stations control the regional mobile phone network and if they are seriously damaged, the entire network could go down. An Airtel staff who spoke on condition of anonymity because he is not authorized to speak to the press said the targeted switch station covered six northern states, including Kano. But while Airtel’s network appeared to be down across Kano Sunday, calls to lines in some of the other states went through.

At about the same time as the Airtel attack, another bomber targeted the facilities of the Nigerian subsidiary of South Africa-based MTN Group Ltd., about two miles (three kilometers) away. That attack was botched by security officers who shot the bomber, causing an explosion at the company’s gate, Ikedichi said.

The target of the foiled attack was MTN’s switch station, said Funmilayo Omogbenigun, spokeswoman for Nigeria’s largest cell phone network provider.

Authorities suspect the Boko Haram sect is behind the attacks. The group is held responsible for more than 770 deaths this year alone, according to figures compiled by The Associated Press. Boko Haram’s campaign of bombings and shootings has targeted mosques, churches, schools, universities and government buildings. But, four months ago, the group broadened its scope by attacking mobile phone towers for the first time.

In September, a series of attacks damaged more than 31 towers operated by all the major mobile phone providers in the country. Other attacks have occurred since then, further straining the one link Nigeria relies on for communication in a country with very few landlines. While no one claimed responsibility for the attacks, the Islamist sect had threatened mobile phone companies earlier in the year, warning that they would be targeted for cooperating with the government to flush out its members.

In Nigeria, Africa’s most populous country with more than 160 million people, mobile phones serve as a valuable lifeline in both cities and rural communities. Landlines remain almost nonexistent, as the state-run telephone company has collapsed and repeated efforts to privatize it have failed. More 87 million mobile phone lines were in use in 2009, according to estimates.

“Never would we have expected that telecommunications could be targeted,” said Damien Udeh, a spokesman for the Association of Licensed Telecommunications Operators of Nigeria. “It portends a dangerous situation for everybody, especially government.”

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Associated Press writer Yinka Ibukun contributed to this report from Lagos, Nigeria

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Falcons top Lions 31-18 for home-field advantage

DETROIT (AP) — Matt Ryan got what he wanted, helping the Atlanta Falcons win a game they needed to earn home-field advantage throughout the NFC playoffs.

Calvin Johnson had to settle for having a record-breaking night in yet another Detroit loss.

Ryan matched a career high with four touchdown passes, two to Roddy White, and Atlanta led from start to finish in a 31-18 victory over Detroit on Saturday night.

Johnson broke Jerry Rice's NFL single-season yards receiving mark of 1,848. Johnson also became the first player with 100 yards receiving in eight straight games and the first with 10 receptions in four games in a row. He had 11 receptions for 225 yards, giving him 1,992 this season.

The Falcons (13-2) pulled away with Ryan's fourth TD pass to wide-open tight end Michael Palmer in the fourth quarter and Matt Bryant's 20-yard field goal with 3:05 left that gave them a 15-point lead.

Ryan was 25 of 32 for 279 yards without a turnover.

Detroit (4-11) dropped its seventh straight game.

The Falcons hope playing at home, potentially throughout the conference playoffs, helps them more than it did after the 2010 and 1980 seasons. The Falcons failed to win a game in either postseason, getting routed by Green Bay two years ago and blowing a double-digit, fourth-quarter lead to Dallas three decades ago.

Atlanta advanced to its only Super bowl with a win at Minnesota after winning a franchise-record 14 games during the 1998 season.

The Falcons won't have much incentive to match that mark next week at home against Tampa Bay, when they'll have nothing to gain and something to lose if a key player or more gets hurt.

The Lions, meanwhile, have been relegated to playing for pride this month and that hasn't been going very well.

Detroit, which has the longest active losing streak in the league, hasn't had this long of a skid since it had one lasting an entire season when the laughingstock of a franchise became the league's first to go 0-16 in 2008.

The Falcons led 21-3 at halftime before letting the Lions pull within five points early in the fourth quarter.

Ryan dashed Detroit's comeback hopes.

Facing intense pressure, he converted a third down in Atlanta territory with a pass to White, picked on rookie cornerback Jonte Green by throwing to Jones to pick up more first downs and found Tony Gonzalez open to convert another third down to set up his fourth TD pass.

Matthew Stafford was clearly trying to get the ball to Johnson on the next drive and cornerback Asante Samuel figured that out, stepping in front of the receiver for an interception to set up Bryant's field goal.

Atlanta running back Michael Turner was tackled in the end zone, after Detroit turned the ball over on downs, to give the Lions two meaningless points.

Johnson began the night 182 yards receiving away from breaking Rice's NFL single-season mark of 1,848 yards receiving set in 1995 with San Francisco.

Johnson was 4 yards away from Rice's record when Detroit kicked a field goal early in the fourth quarter to cut its deficit to five points.

Ryan went deep to White for the first score, connecting with him on a 44-yard TD strike with 5:50 left in the first quarter. Ryan threw a short pass to him early in the second quarter and the standout receiver did the rest on a 39-yard sprint down the sideline.

Ryan put his third TD pass where only Julio Jones could catch it a corner of the end zone, and he did on a 16-yard reception that put Atlanta up 21-3.

Detroit didn't give up, a game after being accused of doing just that in a 38-10 loss at Arizona.

Jason Hanson kicked a second field goal late in the first half to make it 21-6.

After Atlanta opened the second half with a three-and-out drive, Mikel Leshoure scored on a 1-yard run midway through the third quarter to pull the Lions with eight points.

Stafford connected with Johnson on 26- and 21-yard passes during the drive that ended with Hanson's third field goal that made it 21-16.

Stafford finished 37 of 56 for 443 yards without a TD and with one interception.

Detroit dug a big hole because the Falcons scored two TDs off turnovers in the first half.

Defensive end Kroy Biermann forced running Leshoure to fumble, giving the Falcons the ball at their 31 and they took advantage. Ryan's perfectly lofted pass to White's fingertips converted a third-and-1 in a big way, putting the Falcons ahead.

The Lions responded with another drive into Atlanta territory, but stalled and had to settle for Hanson's 34-yard field goal in the final minute of the opening quarter to pull within four points.

Atlanta earned a double-digit lead on the ensuing drive.

Ryan threw a screen pass to his left to White, who got a great block from tight end Gonzalez, and the receiver raced untouched for a score that put the Falcons ahead 14-3.

White finished with eight receptions for 153 yards and two TDs. Jones had seven receptions for 71 yards and a score.

Ryan completed his first 12 attempts and, after his first incomplete pass, he converted a third-and-10 with an 11-yard toss to Jacquizz Rodgers. Two plays later, Ryan matched a season high with a third TD pass on the connection with Jones. Prior to the game, Ryan hadn't started a game with more than 10 consecutive completions, according to STATS LLC. He started 10 for 10 last month against Tampa Bay.

Johnson had three receptions for 70 yards in the first quarter, breaking Herman Moore's single-season franchise record for yards receiving.

By halftime, Johnson had 117 yards receiving. He had 100 yards receiving for an eighth straight game, breaking a record set by Charley Hennigan in 1961 and matched by Michael Irvin in 1995. It was Johnson's 11th game with 100 yards receiving this season, tying Irvin's NFL mark.

The Lions went right to Johnson on their first snap, but he gained just 3 yards on the three-and-out drive. The Falcons drove to the Detroit 45 the first time they had the ball, but punted on a fourth-and-2.

Stafford connected with Johnson on a short crossing route and the receiver did the rest, outrunning Falcons on a 49-yard gain. Fittingly, the Lions turned the ball over on the next snap in the latest lowlight in a season full of them.

The Lions, Falcons and fans at Ford Field in Detroit honored the victims of the shootings at Sandy Hook Elementary School before the game. Players had memorial decals on their helmets that read "S.H.E.S." in white on a black background, and Detroit's coaches wore pins with a similar design. There was also a moment of silence before the national anthem while the names and ages of each victim were shown on the videoboards. Twenty children and six adults were killed in the Dec. 14 shooting in Newtown, Conn. Adam Lanza killed his mother, shot students and staff, then killed himself.

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Follow Larry Lage on Twitter: http://twitter.com/larrylage

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Amazon Book Reviews Deleted in a Purge Aimed at Manipulation

Giving raves to family members is no longer acceptable. Neither is writers’ reviewing other writers. But showering five stars on a book you admittedly have not read is fine.

After several well-publicized cases involving writers buying or manipulating their reviews, Amazon is cracking down. Writers say thousands of reviews have been deleted from the shopping site in recent months.

Amazon has not said how many reviews it has killed, nor has it offered any public explanation. So its sweeping but hazy purge has generated an uproar about what it means to review in an era when everyone is an author and everyone is a reviewer.

Is a review merely a gesture of enthusiasm or should it be held to a higher standard? Should writers be allowed to pass judgment on peers the way they have always done offline or are they competitors whose reviews should be banned? Does a groundswell of raves for a new book mean anything if the author is soliciting the comments?

In a debate percolating on blogs and on Amazon itself, quite a few writers take a permissive view on these issues.

The mystery novelist J. A. Konrath, for example, does not see anything wrong with an author indulging in chicanery. “Customer buys book because of fake review = zero harm,” he wrote on his blog.

Some readers differ. An ad hoc group of purists has formed on Amazon to track its most prominent reviewer, Harriet Klausner, who has over 25,000 reviews. They do not see how she can read so much so fast or why her reviews are overwhelmingly — and, they say, misleadingly — exaltations.

“Everyone in this group will tell you that we’ve all been duped into buying books based on her reviews,” said Margie Brown, a retired city clerk from Arizona.

Once a populist gimmick, the reviews are vital to making sure a new product is not lost in the digital wilderness. Amazon has refined the reviewing process over the years, giving customers the opportunity to rate reviews and comment on them. It is layer after layer of possible criticism.

“A not-insubstantial chunk of their infrastructure is based on their reviews — and all of that depends on having reviews customers can trust,” said Edward W. Robertson, a science fiction novelist who has watched the debate closely.

Nowhere are reviews more crucial than with books, an industry in which Amazon captures nearly a third of every dollar spent. It values reviews more than other online booksellers like Apple or Barnes & Noble, featuring them prominently and using them to help decide which books to acquire for its own imprints by its relatively new publishing arm.

So writers have naturally been vying to get more, and better, notices. Several mystery writers, including R. J. Ellory, Stephen Leather and John Locke, have recently confessed to various forms of manipulation under the general category of “sock puppets,” or online identities used to deceive. That resulted in a widely circulated petition by a loose coalition of writers under the banner, “No Sock Puppets Here Please,” asking people to “vote for book reviews you can trust.”

In explaining its purge of reviews, Amazon has told some writers that “we do not allow reviews on behalf of a person or company with a financial interest in the product or a directly competing product. This includes authors.” But writers say that rule is not applied consistently.

In some cases, the ax fell on those with a direct relationship with the author.

“My sister’s and best friend’s reviews were removed from my books,” the author M. E. Franco said in a blog comment. “They happen to be two of my biggest fans.” Another writer, Valerie X. Armstrong, said her son’s five-star review of her book, “The Survival of the Fattest,” was removed. He immediately tried to put it back “and it wouldn’t take,” she wrote.

In other cases, though, the relationship was more tenuous. Michelle Gagnon lost three reviews on her young adult novel “Don’t Turn Around.” She said she did not know two of the reviewers, while the third was a longtime fan of her work. “How does Amazon know we know each other?” she said. “That’s where I started to get creeped out.”

Mr. Robertson suggested that Amazon applied a broad brush. “I believe they caught a lot of shady reviews, but a lot of innocent ones were erased, too,” he said. He figures the deleted reviews number in the thousands, or perhaps even 10,000.

The explosion of reviews for “The 4-Hour Chef” by Timothy Ferriss shows how the system has evolved from something spontaneous to a means of marketing and promotion. On Nov. 20, publication day, dozens of highly favorable reviews immediately sprouted. Other reviewers quickly criticized Mr. Ferriss, accusing him of buying supporters.

He laughed off those suggestions. “Not only would I never do that — it’s unethical — I simply don’t have to,” he wrote in an e-mail, saying he had sent several hundred review copies to fans and potential fans. “Does that stack the deck? Perhaps, but why send the book to someone who would hate it? That doesn’t help anyone: not the reader, nor the writer.”

As a demonstration of social media’s grip on reviewing, Mr. Ferriss used Twitter and Facebook to ask for a review. “Rallying my readers,” he called it. Within an hour, 61 had complied.

A few of his early reviews were written by people who admitted they had not read the book but were giving it five stars anyway because, well, they knew it would be terrific. “I am looking forward to reading this,” wrote a user posting under the name mhpics.

A spokesman for Amazon, which published “The 4-Hour Chef,” offered this sole comment for this article: “We do not require people to have experienced the product in order to review.”

The dispute over reviews is playing out in the discontent over Mrs. Klausner, an Amazon Hall of Fame reviewer for the last 11 years and undoubtedly one of the most prolific reviewers in literary history.

Mrs. Klausner published review No. 28,366, for “A Red Sun Also Rises” by Mark Hodder. Almost immediately, it had nine critical comments. The first accused it of being “riddled with errors in grammar, spelling and punctuation.” The rest were no more kind. The Harriet Klausner Appreciation Society had struck again.

Mrs. Klausner, a 60-year-old retired librarian who lives in Atlanta, has published an average of seven reviews a day for more than a decade. “To watch her in action is unbelievable,” said her husband, Stanley. “You see the pages turning.”

Mrs. Klausner, who says ailments keep her home and insomnia keeps her up, scoffs at her critics. “You ever read a Harlequin romance?” she said. “You can finish it in one hour. I’ve always been a speed reader.” She has a message for her naysayers: “Get a life. Read a book.”

More than 99.9 percent of Mrs. Klausner’s reviews are four or five stars. “If I can make it past the first 50 pages, that means I like it, and so I review it,” she said. But even Stanley said, “She’s soft, I won’t deny that.”

The campaign against Mrs. Klausner has pushed down her reviewer ratings, which in theory makes her less influential. But when everything is subject to review, the battle is never-ending.

Ragan Buckley, an aspiring novelist active in the campaign against Mrs. Klausner under the name “Sneaky Burrito,” is a little weary. “There are so many fake reviews that I’m often better off just walking into a physical store and picking an item off the shelf at random,” she said.

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